5J6S

Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand

Summary for 5J6S

Entry DOI	10.2210/pdb5j6s/pdb
Descriptor	Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	endoplasmic reticulum, aminopeptidase, hydrolase, zn binding metallopeptidase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	229256.31
Authors	Saridakis, E.,Giastas, P.,Mpakali, A.,Deprez-Poulain, R.,Stratikos, E. (deposition date: 2016-04-05, release date: 2017-03-15, Last modification date: 2024-01-10)
Primary citation	Mpakali, A.,Giastas, P.,Deprez-Poulain, R.,Papakyriakou, A.,Koumantou, D.,Gealageas, R.,Tsoukalidou, S.,Vourloumis, D.,Mavridis, I.M.,Stratikos, E.,Saridakis, E. Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8:333-337, 2017 Cited by PubMed: 28337326 DOI: 10.1021/acsmedchemlett.6b00505 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation