5J6S
Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
Summary for 5J6S
Entry DOI | 10.2210/pdb5j6s/pdb |
Descriptor | Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | endoplasmic reticulum, aminopeptidase, hydrolase, zn binding metallopeptidase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 229256.31 |
Authors | Saridakis, E.,Giastas, P.,Mpakali, A.,Deprez-Poulain, R.,Stratikos, E. (deposition date: 2016-04-05, release date: 2017-03-15, Last modification date: 2024-01-10) |
Primary citation | Mpakali, A.,Giastas, P.,Deprez-Poulain, R.,Papakyriakou, A.,Koumantou, D.,Gealageas, R.,Tsoukalidou, S.,Vourloumis, D.,Mavridis, I.M.,Stratikos, E.,Saridakis, E. Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8:333-337, 2017 Cited by PubMed: 28337326DOI: 10.1021/acsmedchemlett.6b00505 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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