5J6S

Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Endoplasmic reticulum aminopeptidase 2	polymer	967	111563.4	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (Human)	Leukocyte-derived arginine aminopeptidase,L-RAP
2	C, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D, G	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	F	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
7	A, B	(2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide	non-polymer		316.3	2	Chemie (6GA)
8		water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Asn 392	Lys 392	variant
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	223126.8
Branched	Number of molecules	5
	Total formula weight	2932.7
Non-Polymers*	Number of molecules	15
	Total formula weight	3196.8
All*	Total formula weight	229256.3

*Water molecules are not included.