5MJ6
Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.
Summary for 5MJ6
Entry DOI | 10.2210/pdb5mj6/pdb |
Descriptor | Leucyl-cystinyl aminopeptidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | insulin-regulated aminopeptidase, endoplasmatic reticulum aminopeptidases, generation of antigenic peptides for cross-presentation, phosphinic pseudotripeptides, ligand-induced conformational changes, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 217245.27 |
Authors | Mpakali, A.,Stratikos, E.,Saridakis, E.,Giastas, P. (deposition date: 2016-11-30, release date: 2017-04-05, Last modification date: 2024-01-17) |
Primary citation | Mpakali, A.,Saridakis, E.,Harlos, K.,Zhao, Y.,Kokkala, P.,Georgiadis, D.,Giastas, P.,Papakyriakou, A.,Stratikos, E. Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity. J. Med. Chem., 60:2963-2972, 2017 Cited by PubMed: 28328206DOI: 10.1021/acs.jmedchem.6b01890 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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