5MJ6
Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Leucyl-cystinyl aminopeptidase | polymer | 881 | 101182.0 | 2 | UniProt (Q9UIQ6) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (Human) | Cystinyl aminopeptidase,Insulin-regulated membrane aminopeptidase,Insulin-responsive aminopeptidase,IRAP,Oxytocinase,OTase,Placental leucine aminopeptidase,P-LAP |
| 2 | C, R | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 3 | D, F, K, N, P | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E, H, J, L, M... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G, I | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 6 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 7 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 8 | A, B | [(2~{S})-2-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]carbamoyl]-4,4-diphenyl-butyl]-[(1~{R})-1-azanyl-3-phenyl-propyl]phosphinic acid | non-polymer | 597.7 | 2 | Chemie (7O2) | |||
| 9 | A, B | BROMIDE ION | non-polymer | 79.9 | 21 | Chemie (BR) | |||
| 10 | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 1025 (UniProt: Q9UIQ6)
| PDB | External Database | Details |
|---|---|---|
| Arg 1026 | - | expression tag |
| Thr 1027 | - | expression tag |
| Glu 1028 | - | expression tag |
| Thr 1029 | - | expression tag |
| Ser 1030 | - | expression tag |
| Gln 1031 | - | expression tag |
| Val 1032 | - | expression tag |
| Ala 1033 | - | expression tag |
| Pro 1034 | - | expression tag |
| Ala 1035 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 202364.1 | |
| Branched | Number of molecules | 16 |
| Total formula weight | 9222.5 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 5658.7 | |
| All* | Total formula weight | 217245.3 |
