6SST
| cryo-em structure of alpha-synuclein fibril polymorph 2B | Descriptor: | Alpha-synuclein | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | Deposit date: | 2019-09-09 | Release date: | 2019-12-18 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
|
|
6SSX
| cryo-em structure of alpha-synuclein fibril polymorph 2A | Descriptor: | Alpha-synuclein | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | Deposit date: | 2019-09-09 | Release date: | 2019-12-18 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
|
|
6PEO
| Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | Descriptor: | Alpha-synuclein | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | Deposit date: | 2019-06-20 | Release date: | 2019-11-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
|
|
8OQI
| Cryo-EM structure of the wild-type alpha-synuclein fibril. | Descriptor: | Alpha-synuclein | Authors: | Pesch, V, Reithofer, S, Ma, L, Flores-Fernandez, J.M, Oezduezenciler, P, Busch, Y, Lien, Y, Rudtke, O, Frieg, B, Schroeder, G.F, Wille, H, Tamgueney, G. | Deposit date: | 2023-04-12 | Release date: | 2024-03-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease. Brain, 147, 2024
|
|
8RQM
| Alpha-synuclein amyloid fibrils | Descriptor: | Alpha-synuclein | Authors: | Saibil, H.R, Monistrol, J. | Deposit date: | 2024-01-18 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly Biorxiv, 2024
|
|
8RRR
| Alpha-synuclein amyloid fibril | Descriptor: | Alpha-synuclein | Authors: | Saibil, H.R, Monistrol, J. | Deposit date: | 2024-01-23 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly Biorxiv, 2024
|
|
8RI9
| Late alpha-Synuclein fibril structure from liquid-liquid phase separations. | Descriptor: | Alpha-synuclein | Authors: | De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G. | Deposit date: | 2023-12-18 | Release date: | 2024-03-06 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates. J.Am.Chem.Soc., 146, 2024
|
|
6UFR
| Structure of recombinantly assembled E46K alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | Deposit date: | 2019-09-24 | Release date: | 2020-02-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7LC9
| |
7L7H
| Alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Hojjatian, A, Dasari, A. | Deposit date: | 2020-12-28 | Release date: | 2022-01-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Distinct cryo-EM Structure of Alpha-synuclein Filaments derived by Tau To Be Published
|
|
7NCJ
| |
7NCG
| |
7NCI
| |
7NCA
| |
7NCH
| |
7NCK
| |
8FPT
| STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE | Descriptor: | Alpha-synuclein | Authors: | Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. | Deposit date: | 2023-01-05 | Release date: | 2023-02-22 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
|
|
8H05
| |
8H04
| |
8H03
| |
8GF7
| Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein | Authors: | Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M. | Deposit date: | 2023-03-07 | Release date: | 2023-11-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology. Nat.Chem.Biol., 20, 2024
|
|
8HZC
| |
8HZS
| |
8HZB
| |
8JEX
| Cryo-EM structure of alpha-synuclein gS87 fibril | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein, unverified amino acid chain | Authors: | Xia, W.C, Sun, Y.P, Liu, C. | Deposit date: | 2023-05-16 | Release date: | 2024-04-17 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures. Nat Commun, 15, 2024
|
|