7NCI

Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1

Summary for 7NCI

• Entry DOI: 10.2210/pdb7nci/pdb
• EMDB information: 12267
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: amyloid, multiple system atrophy, neurodegeneration, alpha-synuclein, filament, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 173713.30

Authors

Lovestam, S.K.A.,Schweighauser, M.,Scheres, S.H.W. (deposition date: 2021-01-28, release date: 2021-02-24, Last modification date: 2021-04-14)

• Primary citation: Lovestam, S.,Schweighauser, M.,Matsubara, T.,Murayama, S.,Tomita, T.,Ando, T.,Hasegawa, K.,Yoshida, M.,Tarutani, A.,Hasegawa, M.,Goedert, M.,Scheres, S.H.W.; Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.; Febs Open Bio, 11:999-1013, 2021; PubMed: 33548114; DOI: 10.1002/2211-5463.13110

Experimental method

ELECTRON MICROSCOPY (3.55 Å)