7RG9
 
 | | cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | | 登録日 | 2021-07-14 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA3
 | | cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP | | 分子名称: | Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | | 登録日 | 2021-06-29 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7RGP
 | | cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | | 登録日 | 2021-07-15 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7RBT
 | | cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | | 分子名称: | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | | 登録日 | 2021-07-06 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural determinants of dual incretin receptor agonism by tirzepatide.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7WVX
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVW
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | | 分子名称: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVV
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | | 分子名称: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVU
 | | Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | | 分子名称: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7EJ8
 | | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine | | 分子名称: | Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | | 登録日 | 2021-04-01 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
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7EJ0
 | | Structure of the alpha2A-adrenergic receptor GoA signaling complex | | 分子名称: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | | 登録日 | 2021-04-01 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
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7EJA
 | | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine | | 分子名称: | 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | | 登録日 | 2021-04-01 | | 公開日 | 2022-04-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
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7EJK
 | | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline | | 分子名称: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | | 登録日 | 2021-04-02 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
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7EJX
 | | Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand | | 分子名称: | (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, J, Chen, G, Liu, Z, Du, Y. | | 登録日 | 2021-04-02 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
Nat Commun, 13, 2022
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7SCG
 | | FH210 bound Mu Opioid Receptor-Gi Protein Complex | | 分子名称: | (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, H, Kobilka, B. | | 登録日 | 2021-09-28 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7SBF
 | | PZM21 bound Mu Opioid Receptor-Gi Protein Complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B. | | 登録日 | 2021-09-24 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7W53
 | | Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7WQ4
 | | Galanin-bound galanin receptor 2 in complex with Gq | | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | | 登録日 | 2022-01-24 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
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7W57
 | | Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7W55
 | | Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7WQ3
 | | Galanin-bound galanin receptor 1 in complex with Gi | | 分子名称: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | | 登録日 | 2022-01-24 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
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7W56
 | | Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7SF7
 | | LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer | | 分子名称: | G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Barros-Alvarez, X, Panova, O, Skiniotis, G. | | 登録日 | 2021-10-03 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | The tethered peptide activation mechanism of adhesion GPCRs.
Nature, 604, 2022
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7SF8
 | | GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer | | 分子名称: | G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Barros-Alvarez, X, Panova, O, Skiniotis, G. | | 登録日 | 2021-10-03 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | The tethered peptide activation mechanism of adhesion GPCRs.
Nature, 604, 2022
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7WU4
 | | Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGi | | 分子名称: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | | 登録日 | 2022-02-05 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1.
Nature, 604, 2022
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