7RG9

cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form

Summary for 7RG9

• Entry DOI: 10.2210/pdb7rg9/pdb
• Related: 7RA3 7RBT
• EMDB information: 24445
• Descriptor: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Single-chain variable fragment 16, ... (6 entities in total)
• Functional Keywords: class b gpcr, glucagon-like peptide-1 receptor, g protein nucleotide exchange factor., membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 190236.69

Authors

Sun, B.,Kobilka, B.K.,Sloop, K.W.,Feng, D.,Kobilka, T.S. (deposition date: 2021-07-14, release date: 2022-04-13)

• Primary citation: Sun, B.,Willard, F.S.,Feng, D.,Alsina-Fernandez, J.,Chen, Q.,Vieth, M.,Ho, J.D.,Showalter, A.D.,Stutsman, C.,Ding, L.,Suter, T.M.,Dunbar, J.D.,Carpenter, J.W.,Mohammed, F.A.,Aihara, E.,Brown, R.A.,Bueno, A.B.,Emmerson, P.J.,Moyers, J.S.,Kobilka, T.S.,Coghlan, M.P.,Kobilka, B.K.,Sloop, K.W.; Structural determinants of dual incretin receptor agonism by tirzepatide.; Proc.Natl.Acad.Sci.USA, 119:e2116506119-e2116506119, 2022; PubMed: 35333651; DOI: 10.1073/pnas.2116506119

Experimental method

ELECTRON MICROSCOPY (3.2 Å)