8HQN
| Activation mechanism of GPR132 by 9(S)-HODE | 分子名称: | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HPT
| Structure of C5a-pep bound mouse C5aR1 in complex with Go | 分子名称: | Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2022-12-13 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
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8HQC
| Structure of a GPCR-G protein in complex with a natural peptide agonist | 分子名称: | Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | 著者 | Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2022-12-13 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
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8HQE
| Cryo-EM structure of the apo-GPR132-Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQM
| Activation mechanism of GPR132 by NPGLY | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HOC
| Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex | 分子名称: | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. | 登録日 | 2022-12-09 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit To Be Published
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8HNM
| CXCR3-DNGi complex activated by VUF11222 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HNK
| CXCR3-DNGi complex activated by CXCL11 | 分子名称: | C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HNL
| CXCR3-DNGi complex activated by PS372424 | 分子名称: | (3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HN8
| Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. | 登録日 | 2022-12-07 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit To Be Published
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8FEG
| CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 | 分子名称: | ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Fay, J.F, Che, T. | 登録日 | 2022-12-06 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. Nat Commun, 14, 2023
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8HMV
| Structure of GPR21-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Wong, T.S, Gao, W. | 登録日 | 2022-12-05 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020), 4, 2023
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8HMP
| GPR52 with Gs and c17 | 分子名称: | G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B, Xu, F. | 登録日 | 2022-12-05 | 公開日 | 2023-06-21 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19 F-NMR and cryo-electron microscopy. MedComm (2020), 4, 2023
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8HK3
| C3aR-Gi-apo protein complex | 分子名称: | C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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8HK2
| C3aR-Gi-C3a protein complex | 分子名称: | C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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8HK5
| C5aR1-Gi-C5a protein complex | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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8HJ1
| GPR21(wt) and Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, B, Lin, X, Xu, F. | 登録日 | 2022-11-22 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HIX
| Cryo-EM structure of GPR21_m5_Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, B, Lin, X, Xu, F. | 登録日 | 2022-11-22 | 公開日 | 2023-03-15 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HJ0
| GPR21(m5) and G15 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, B, Lin, X. | 登録日 | 2022-11-22 | 公開日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HJ2
| GPR21 wt with G15 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, B, Lin, X, Xu, F. | 登録日 | 2022-11-22 | 公開日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HJ5
| Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | Gan, B, Yu, L.Y, Ren, R.B. | 登録日 | 2022-11-22 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Plos Biol., 21, 2023
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8F7R
| Gi bound mu-opioid receptor in complex with endomorphin | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7W
| Gi bound kappa-opioid receptor in complex with dynorphin | 分子名称: | CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7X
| Gi bound nociceptin receptor in complex with nociceptin peptide | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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8F7Q
| Gi bound mu-opioid receptor in complex with beta-endorphin | 分子名称: | Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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