8XQK
 
 | | The Crystal Structure of Apaf from Biortus. | | Descriptor: | Apoptotic protease-activating factor 1, PHOSPHATE ION | | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. | | Deposit date: | 2024-01-05 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The Crystal Structure of Apaf from Biortus.
To Be Published
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3CRD
 | | NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES | | Descriptor: | RAIDD | | Authors: | Chou, J.J, Matsuo, H, Duan, H, Wagner, G. | | Deposit date: | 1998-07-24 | | Release date: | 1999-02-02 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.
Cell(Cambridge,Mass.), 94, 1998
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2DBD
 | | Solution structure of the CARD domain in human caspase recruitment domain protein 4 (Nod1 protein) | | Descriptor: | Caspase recruitment domain protein 4 | | Authors: | Saito, K, Inoue, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-12-15 | | Release date: | 2006-12-19 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the CARD domain in human caspase recruitment domain protein 4 (Nod1 protein)
To be Published
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4E9M
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4UZ0
 | | Crystal Structure of apoptosis repressor with CARD (ARC) | | Descriptor: | GLYCEROL, NUCLEOLAR PROTEIN 3 | | Authors: | Kim, S.H, Jeong, J.H, Jang, T.H, Kim, Y.G, Park, H.H. | | Deposit date: | 2014-09-04 | | Release date: | 2015-07-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.399 Å) | | Cite: | Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis.
Sci.Rep., 5, 2015
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4RHW
 | | Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | | Descriptor: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | | Authors: | Hu, Q, Wu, D, Yan, C, Shi, Y. | | Deposit date: | 2014-10-03 | | Release date: | 2014-10-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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2YGS
 | | CARD DOMAIN FROM APAF-1 | | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | | Authors: | Shi, Y. | | Deposit date: | 1999-05-08 | | Release date: | 2000-04-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature, 399, 1999
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3YGS
 | | APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9 | | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1, PROCASPASE 9 | | Authors: | Qin, H, Srinivasula, S, Wu, G, Fernandes-Alnemri, T, Alnemri, E, Shi, Y. | | Deposit date: | 1999-05-08 | | Release date: | 2000-04-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature, 399, 1999
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1C15
 | | SOLUTION STRUCTURE OF APAF-1 CARD | | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | | Authors: | Zhou, P, Chou, J, Olea, R.S, Yuan, J, Wagner, G. | | Deposit date: | 1999-07-20 | | Release date: | 1999-09-20 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
Proc.Natl.Acad.Sci.USA, 96, 1999
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6BZE
 | | Cryo-EM structure of BCL10 CARD filament | | Descriptor: | B-cell lymphoma/leukemia 10 | | Authors: | David, L, Li, Y, Ma, J, Garner, E, Zhang, X, Wu, H. | | Deposit date: | 2017-12-23 | | Release date: | 2018-02-14 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8CZO
 | | Cryo-EM structure of BCL10 CARD - MALT1 DD filament | | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | Authors: | David, L, Wu, H. | | Deposit date: | 2022-05-25 | | Release date: | 2022-06-22 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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8CZD
 | | Cryo-EM structure of BCL10 R58Q filament | | Descriptor: | B-cell lymphoma/leukemia 10 | | Authors: | David, L, Wu, H. | | Deposit date: | 2022-05-24 | | Release date: | 2022-06-22 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
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6K7V
 | | Structure of NLRP1 CARD filament | | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | | Authors: | Gong, Q, Xu, C, Zhang, J, Wu, B. | | Deposit date: | 2019-06-09 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Nat Commun, 12, 2021
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1CWW
 | | SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1 | | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | | Authors: | Day, C.L, Dupont, C, Lackmann, M, Vaux, D.L, Hinds, M.G. | | Deposit date: | 1999-08-26 | | Release date: | 2000-01-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.
Cell Death Differ., 6, 1999
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1CY5
 | | CRYSTAL STRUCTURE OF THE APAF-1 CARD | | Descriptor: | BETA-MERCAPTOETHANOL, PROTEIN (APOPTOTIC PROTEASE ACTIVATING FACTOR 1), ZINC ION | | Authors: | Vaughn, D.E, Joshua-Tor, L. | | Deposit date: | 1999-08-31 | | Release date: | 1999-09-13 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.
J.Mol.Biol., 293, 1999
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6K9F
 | | Structure of unknow protein 4 | | Descriptor: | Caspase recruitment domain-containing protein 8 | | Authors: | Gong, Q, Xu, C, Zhang, J, Boo, Z.Z, Wu, B. | | Deposit date: | 2019-06-15 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Nat Commun, 12, 2021
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6K99
 | | Structure of ASC CARD filament | | Descriptor: | Apoptosis-associated speck-like protein containing a CARD | | Authors: | Gong, Q, Xu, C, Zhang, J, Boo, Z.Z, Wu, B. | | Deposit date: | 2019-06-14 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Nat Commun, 12, 2021
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1DGN
 | | SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION | | Descriptor: | ICEBERG (PROTEASE INHIBITOR) | | Authors: | Humke, E.W, Shriver, S.K, Starovasnik, M.A, Fairbrother, W.J, Dixit, V.M. | | Deposit date: | 1999-11-24 | | Release date: | 2000-10-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell(Cambridge,Mass.), 103, 2000
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5YRN
 | | Structure of RIP2 CARD domain | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 2 | | Authors: | Wu, B, Gong, Q. | | Deposit date: | 2017-11-09 | | Release date: | 2018-11-14 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of RIP2 activation and signaling.
Nat Commun, 9, 2018
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5WVC
 | | Structure of the CARD-CARD disk | | Descriptor: | Apoptotic protease-activating factor 1, Caspase, IODIDE ION | | Authors: | Lin, S.C, Lo, Y.C, Su, T.W. | | Deposit date: | 2016-12-24 | | Release date: | 2017-04-19 | | Method: | X-RAY DIFFRACTION (2.993 Å) | | Cite: | Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.
Structure, 25, 2017
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2B1W
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5FNA
 | | Cryo-EM reconstruction of caspase-1 CARD | | Descriptor: | Caspase-1 | | Authors: | Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H. | | Deposit date: | 2015-11-11 | | Release date: | 2016-03-30 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
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5H8O
 | | Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, VHH nanobody | | Authors: | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | | Deposit date: | 2015-12-23 | | Release date: | 2016-04-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (4.206 Å) | | Cite: | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
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2L9M
 | | Structure of cIAP1 CARD | | Descriptor: | Baculoviral IAP repeat-containing protein 2 | | Authors: | Day, C.L, Rautureau, G.J.P, Hinds, M.G. | | Deposit date: | 2011-02-21 | | Release date: | 2011-08-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.
Mol.Cell, 42, 2011
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2MB9
 | | Human Bcl10 CARD | | Descriptor: | B-cell lymphoma/leukemia 10 | | Authors: | Zheng, C, Bracken, C, Wu, H. | | Deposit date: | 2013-07-26 | | Release date: | 2013-10-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.
Mol.Cell, 51, 2013
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