6K99

Structure of ASC CARD filament

Summary for 6K99

• Entry DOI: 10.2210/pdb6k99/pdb
• EMDB information: 9947
• Descriptor: Apoptosis-associated speck-like protein containing a CARD (1 entity in total)
• Functional Keywords: filament, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 117301.72

Authors

Gong, Q.,Xu, C.,Zhang, J.,Boo, Z.Z.,Wu, B. (deposition date: 2019-06-14, release date: 2020-09-16, Last modification date: 2024-03-27)

• Primary citation: Gong, Q.,Robinson, K.,Xu, C.,Huynh, P.T.,Chong, K.H.C.,Tan, E.Y.J.,Zhang, J.,Boo, Z.Z.,Teo, D.E.T.,Lay, K.,Zhang, Y.,Lim, J.S.Y.,Goh, W.I.,Wright, G.,Zhong, F.L.,Reversade, B.,Wu, B.; Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.; Nat Commun, 12:188-188, 2021; PubMed: 33420028; DOI: 10.1038/s41467-020-20319-5

Experimental method

ELECTRON MICROSCOPY (4.1 Å)