PDB: 109 件ウェブページステータス検索Chemie searchBIRD

---

2CRP	Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5) 分子名称: Regulator of G-protein signaling 5 著者 Zhang, H.P, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-20 公開日 2005-11-20 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5) To be Published
2D9J	Solution structure of the RGS domain of Regulator of G-protein signaling 7 分子名称: Regulator of G-protein signalling 7 著者 Zhang, H.P, Nagasima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-09 公開日 2006-12-09 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the RGS domain of Regulator of G-protein signaling 7 to be published
2DLR	Solution structure of the RGS domain of human Regulator of G-protein signaling 10 分子名称: Regulator of G-protein signaling 10 著者 Zhang, H.P, Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-20 公開日 2006-10-20 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the RGS domain of human Regulator of G-protein signaling 10 To be published
2DLV	Solution structure of the RGS domain of human regulator of G-protein signaling 18 分子名称: Regulator of G-protein signaling 18 著者 Zhang, H.P, Suetake, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-20 公開日 2007-04-17 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the RGS domain of human regulator of G-protein signaling 18 to be published
2EBZ	Solution structure of the RGS domain from human Regulator of G-protein signaling 12 (RGS12) 分子名称: Regulator of G-protein signaling 12 著者 Zhang, H.P, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-02-09 公開日 2008-03-04 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the RGS domain from human Regulator of G-protein signaling 12 (RGS12) To be Published
2ES0	Structure of the regulator of G-protein signaling domain of RGS6 分子名称: regulator of G-protein signalling 6 著者 Schoch, G.A, Phillips, C, Turnbull, A, Niesen, F, Johansson, C, Elkins, J.M, Longman, E, Gilealdi, C, Sobott, F, Ball, L, Sundstrom, M, Edwards, A, Arrowsmith, C, von Delft, F, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2005-10-25 公開日 2005-11-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
1EMU	STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC 分子名称: ADENOMATOUS POLYPOSIS COLI PROTEIN, AXIN, GLYCEROL 著者 Spink, K.E, Polakis, P, Weis, W.I. 登録日 2000-03-17 公開日 2000-07-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of the Axin-adenomatous polyposis coli interaction. EMBO J., 19, 2000
4GOU	Crystal structure of an RGS-RhoGEF from Entamoeba histolytica 分子名称: EhRGS-RhoGEF 著者 Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P. 登録日 2012-08-20 公開日 2013-01-09 最終更新日 2013-01-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis. Structure, 21, 2013
3CIK	Human GRK2 in Complex with Gbetagamma subunits 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Tesmer, J.J.G, Lodowski, D.T. 登録日 2008-03-11 公開日 2009-02-17 最終更新日 2012-03-07 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53, 2010
6PJX	Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM) 分子名称: CALCIUM ION, Calmodulin, G protein-coupled receptor kinase 5, ... 著者 Bhardwaj, A, Komolov, K.E, Sulon, S, Benovic, J.L. 登録日 2019-06-28 公開日 2020-12-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol.Cell, 81, 2021
7PWD	Structure of an inhibited GRK2-G-beta and G-gamma complex 分子名称: 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ... 著者 Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M. 登録日 2021-10-06 公開日 2021-10-20 最終更新日 2022-05-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747 分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2019-09-02 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
6N9G	Crystal Structure of RGS7-Gbeta5 dimer 分子名称: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 著者 Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. 登録日 2018-12-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.129 Å) 主引用文献 Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex. Elife, 7, 2018
5DO9	Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... 著者 Taylor, V.G, Tesmer, J.J.G. 登録日 2015-09-10 公開日 2016-01-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY. J.Biol.Chem., 291, 2016
1OMW	Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits 分子名称: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 著者 Lodowski, D.T, Pitcher, J.A, Capel, W.D, Lefkowitz, R.J, Tesmer, J.J.G. 登録日 2003-02-26 公開日 2003-06-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma Science, 300, 2003
1AGR	COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4 分子名称: CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1997-03-25 公開日 1997-06-16 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell(Cambridge,Mass.), 89, 1997
8UAQ	Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21 分子名称: (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 著者 Chen, Y, Tesmer, J.J.G. 登録日 2023-09-21 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. Eur.J.Med.Chem., 264, 2023
8UAP	Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441 分子名称: (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 著者 Chen, Y, Tesmer, J.J.G. 登録日 2023-09-21 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. Eur.J.Med.Chem., 264, 2023
4WBO	Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox 分子名称: 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, CHLORIDE ION, Rhodopsin kinase 著者 Homan, K.T, Tesmer, J.J.G. 登録日 2014-09-03 公開日 2014-11-05 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Identification and characterization of amlexanox as a g protein-coupled receptor kinase 5 inhibitor. Molecules, 19, 2014
5WG3	Human GRK2 in complex with Gbetagamma subunits and CCG258748 分子名称: 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(1H-pyrazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2017-07-13 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
2PBI	The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure 分子名称: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 著者 Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. 登録日 2007-03-28 公開日 2008-01-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat.Struct.Mol.Biol., 15, 2008
4WNK	Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022 分子名称: (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, G protein-coupled receptor kinase 5, SULFATE ION 著者 Homan, K.T, Tesmer, J.J.G. 登録日 2014-10-13 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J.Biol.Chem., 290, 2015
3V5W	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine 分子名称: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Thal, D.M, Tesmer, J.J.G. 登録日 2011-12-17 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chem.Biol., 7, 2012
3UZT	Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2 分子名称: Beta-adrenergic receptor kinase 1, C13.18 RNA Aptamer, MAGNESIUM ION 著者 Tesmer, J.J.G, Tesmer, V.M. 登録日 2011-12-07 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure, 20, 2012
7SHF	Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex 分子名称: (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ... 著者 Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A. 登録日 2021-10-08 公開日 2021-12-01 最終更新日 2022-01-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex. Science, 375, 2022

<12345>