8SIA
 
 | | Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in closed state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CALCIUM ION, ... | | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-04-14 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
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7MZ6
 | | Cryo-EM structure of minimal TRPV1 with 1 perturbed PI | | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2021-05-24 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
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8X93
 | | P/Q type calcium channel in complex with omega-Agatoxin IVA | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T. | | 登録日 | 2023-11-29 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels.
Cell Res., 2024
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8VJK
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3ZJZ
 | | Open-form NavMS Sodium Channel Pore (with C-terminal Domain) | | 分子名称: | DODECAETHYLENE GLYCOL, HEGA-10, ION TRANSPORT PROTEIN, ... | | 著者 | Bagneris, C, Naylor, C.E, Wallace, B.A. | | 登録日 | 2013-01-21 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Role of the C-Terminal Domain in the Structure and Function of Tetrameric Sodium Channels.
Nat.Commun., 4, 2013
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8F1C
 | | Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4) | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one, POTASSIUM ION, ... | | 著者 | Chen, Y, Ishchenko, A. | | 登録日 | 2022-11-04 | | 公開日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SRC
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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7UA4
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7RHS
 | | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cyclic nucleotide-gated cation channel alpha-3, Cyclic nucleotide-gated cation channel beta-3, ... | | 著者 | Zheng, X, Yang, J. | | 登録日 | 2021-07-18 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structure of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 29, 2022
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7RJT
 | | Aplysia Slo1 with Barium | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, BARIUM ION, BK channel, ... | | 著者 | Zhu, J, Srivastava, S, Cachau, R, Holmgren, M. | | 登録日 | 2021-07-21 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | CryoEM structure of Aplysia Slo1 with 10 mM Ba2+ at 2.93 A
To Be Published
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8SRA
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7XJ1
 | | Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
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8TF3
 | | Wildtype rabbit TRPV5 into nanodiscs in complex with econazole | | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | | 著者 | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | | 登録日 | 2023-07-07 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
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7ZJD
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8F1D
 | | Voltage-gated potassium channel Kv3.1 apo | | 分子名称: | CHOLESTEROL, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1, ... | | 著者 | Chen, Y, Ishchenko, A. | | 登録日 | 2022-11-04 | | 公開日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8X90
 | | P/Q type calcium channel | | 分子名称: | 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T. | | 登録日 | 2023-11-29 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels.
Cell Res., 2024
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5HK7
 | | Bacterial sodium channel pore, 2.95 Angstrom resolution | | 分子名称: | 2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}ethyl heptadecanoate, CHLORIDE ION, Ion transport protein, ... | | 著者 | Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L. | | 登録日 | 2016-01-14 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
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3RW0
 | | Crystal structure of the NavAb voltage-gated sodium channel (Met221Cys, 2.95 A) | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein | | 著者 | Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2011-05-06 | | 公開日 | 2011-07-13 | | 最終更新日 | 2011-07-27 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
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8SD3
 | | CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | | 著者 | Tan, X, Swartz, K.J. | | 登録日 | 2023-04-06 | | 公開日 | 2023-09-27 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
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5IRX
 | | Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | | 分子名称: | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | | 著者 | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | 登録日 | 2016-03-14 | | 公開日 | 2016-05-25 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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8FFN
 | | RR-bound wildtype rabbit TRPV5 in nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... | | 著者 | Fluck, E.C, De Jesus-Perez, J.J, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. | | 登録日 | 2022-12-09 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Molecular details of ruthenium red pore block in TRPV channels.
Embo Rep., 25, 2024
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7VNQ
 | | Structure of human KCNQ4-ML213 complex in nanodisc | | 分子名称: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | | 著者 | Xu, F, Zheng, Y. | | 登録日 | 2021-10-11 | | 公開日 | 2021-12-01 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
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7LHF
 | | Structure of full-length IP3R1 channel solubilized in LNMG & lipid in the apo-state | | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, Inositol 1,4,5-trisphosphate receptor type 1, ZINC ION | | 著者 | Baker, M.R, Fan, G, Baker, M.L, Serysheva, I.I. | | 登録日 | 2021-01-22 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
Commun Biol, 4, 2021
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7UA3
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8UQ2
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