8F1C

Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4)

Summary for 8F1C

• Entry DOI: 10.2210/pdb8f1c/pdb
• EMDB information: 28793 28795
• Descriptor: Potassium voltage-gated channel subfamily C member 1, ZINC ION, (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one, ... (5 entities in total)
• Functional Keywords: ion channel, positive modulator, voltage gated, voltage gated potassium channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 256190.91

Authors

Chen, Y.,Ishchenko, A. (deposition date: 2022-11-04, release date: 2023-10-25)

• Primary citation: Chen, Y.T.,Hong, M.R.,Zhang, X.J.,Kostas, J.,Li, Y.,Kraus, R.L.,Santarelli, V.P.,Wang, D.,Gomez-Llorente, Y.,Brooun, A.,Strickland, C.,Soisson, S.M.,Klein, D.J.,Ginnetti, A.T.,Marino, M.J.,Stachel, S.J.,Ishchenko, A.; Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.; Proc.Natl.Acad.Sci.USA, 120:e2220029120-e2220029120, 2023; PubMed: 37812700; DOI: 10.1073/pnas.2220029120

Experimental method

ELECTRON MICROSCOPY (2.92 Å)