7UA3

Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin

This is a non-PDB format compatible entry.

Summary for 7UA3

• Entry DOI: 10.2210/pdb7ua3/pdb
• EMDB information: 26413
• Descriptor: Ryanodine receptor 2, Peptidyl-prolyl cis-trans isomerase FKBP1B, Calmodulin-1, ... (5 entities in total)
• Functional Keywords: calcium channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 2379787.27

Authors

Miotto, M.C.,Marks, A.R. (deposition date: 2022-03-11, release date: 2022-08-03)

• Primary citation: Miotto, M.C.,Weninger, G.,Dridi, H.,Yuan, Q.,Liu, Y.,Wronska, A.,Melville, Z.,Sittenfeld, L.,Reiken, S.,Marks, A.R.; Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.; Sci Adv, 8:eabo1272-eabo1272, 2022; PubMed: 35857850; DOI: 10.1126/sciadv.abo1272

Experimental method

ELECTRON MICROSCOPY (2.97 Å)