7XJ1

Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry

Summary for 7XJ1

• Entry DOI: 10.2210/pdb7xj1/pdb
• EMDB information: 33216
• Descriptor: Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide (3 entities in total)
• Functional Keywords: channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 495426.06

Authors

Fan, J.,Yue, Z.,Jiang, D.,Lei, X. (deposition date: 2022-04-14, release date: 2022-11-09, Last modification date: 2023-01-11)

• Primary citation: Fan, J.,Hu, L.,Yue, Z.,Liao, D.,Guo, F.,Ke, H.,Jiang, D.,Yang, Y.,Lei, X.; Structural basis of TRPV3 inhibition by an antagonist.; Nat.Chem.Biol., 19:81-90, 2023; PubMed: 36302896; DOI: 10.1038/s41589-022-01166-5

Experimental method

ELECTRON MICROSCOPY (2.93 Å)