3I1H
 
 | | Crystal structure of human BFL-1 in complex with BAK BH3 peptide | | 分子名称: | Apoptosis regulator BAK, Protein BFL-1 | | 著者 | Guan, R, Xiao, R, Zhao, L, Acton, T, White, E, Gelinas, C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2009-06-26 | | 公開日 | 2009-07-14 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | crystal structure of human BFL-1 in complex with BAK BH3 peptide
To be Published
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3KZ0
 | | MCL-1 complex with MCL-1-specific selected peptide | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 specific peptide MB7, SULFATE ION, ... | | 著者 | Dutta, S, Fire, E, Grant, R.A, Sauer, R.T, Keating, A.E. | | 登録日 | 2009-12-07 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | | 主引用文献 | Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
J.Mol.Biol., 398, 2010
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8G1T
 | | Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21 | | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX | | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S. | | 登録日 | 2023-02-02 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 2023
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4BPJ
 | | Mcl-1 bound to alpha beta Puma BH3 peptide 3 | | 分子名称: | ALPHA BETA BH3-PEPTIDE, CHLORIDE ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG, ... | | 著者 | Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2013-05-27 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.
Chembiochem, 14, 2013
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4BPI
 | | Mcl-1 bound to alpha beta Puma BH3 peptide 2 | | 分子名称: | ALPHA BETA BH3PEPTIDE, CADMIUM ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG | | 著者 | Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2013-05-27 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | | 主引用文献 | Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.
Chembiochem, 14, 2013
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8H7B
 | | The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA | | 分子名称: | 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Zhu, C.J, Zhang, Z.M. | | 登録日 | 2022-10-19 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.46408451 Å) | | 主引用文献 | 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
J.Am.Chem.Soc., 2023
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4BD7
 | | Bax domain swapped dimer induced by octylmaltoside | | 分子名称: | APOPTOSIS REGULATOR BAX, CHLORIDE ION, PRASEODYMIUM ION | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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8IQM
 | | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins | | 分子名称: | Bcl2 modifying factor, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.967 Å) | | 主引用文献 | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
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8IGC
 | | Crystal structure of Bak bound to Bnip5 BH3 | | 分子名称: | Bcl-2 homologous antagonist/killer, Protein BNIP5 | | 著者 | Ku, B, Lim, D. | | 登録日 | 2023-02-20 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | | 主引用文献 | Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain-containing protein.
Proteins, 92, 2024
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4BD8
 | | Bax domain swapped dimer induced by BimBH3 with CHAPS | | 分子名称: | 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD2
 | | Bax domain swapped dimer in complex with BidBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-04 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD6
 | | Bax domain swapped dimer in complex with BaxBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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6QFC
 | | Structure of an anti-Mcl1 scFv | | 分子名称: | DIMETHYL SULFOXIDE, Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55 | | 著者 | Luptak, J. | | 登録日 | 2019-01-09 | | 公開日 | 2019-11-06 | | 最終更新日 | 2019-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
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6QFQ
 | | Structure of human Mcl-1 in complex with indole acid inhibitor | | 分子名称: | 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QFM
 | | Structure of human Mcl-1 in complex with PUMA BH3 peptide | | 分子名称: | Bcl-2-binding component 3, CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | 登録日 | 2019-01-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QZB
 | | Structure of Mcl-1 in complex with compound 8d | | 分子名称: | (2~{R})-2-[[6-ethyl-5-(2-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. | | 登録日 | 2019-03-11 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
J.Med.Chem., 62, 2019
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2M5B
 | | The NMR structure of the BID-BAK complex | | 分子名称: | Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB | | 著者 | Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R. | | 登録日 | 2013-02-19 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
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2MHS
 | | NMR Structure of human Mcl-1 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Liu, G, Poppe, L, Aoki, K, Yamane, H, Lewis, J, Szyperski, T. | | 登録日 | 2013-12-04 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
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5W60
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5W61
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5W63
 | | Crystal structure of channel catfish BAX | | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator bax, SULFATE ION | | 著者 | Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S. | | 登録日 | 2017-06-16 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.436 Å) | | 主引用文献 | Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
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5W89
 | | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18 | | 著者 | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | | 登録日 | 2017-06-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WHI
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5W8F
 | | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14 | | 著者 | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | | 登録日 | 2017-06-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WDD
 | | Crystal structure of chicken BOK | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2-related ovarian killer protein | | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-07-04 | | 公開日 | 2018-02-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | | 主引用文献 | Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Cell, 173, 2018
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