8H7B

The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA

Summary for 8H7B

Entry DOI	10.2210/pdb8h7b/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid (3 entities in total)
Functional Keywords	complex, inhibitor, lysine, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	36011.04
Authors	Zhu, C.J.,Zhang, Z.M. (deposition date: 2022-10-19, release date: 2023-02-22, Last modification date: 2024-02-07)
Primary citation	Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q. 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J.Am.Chem.Soc., 2023 Cited by PubMed: 36774655 DOI: 10.1021/jacs.2c11595 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4640844632 Å)

Structure validation