8H7B
The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 152 | 17408.8 | 2 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | A, B | 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid | non-polymer | 596.7 | 2 | Chemie (QHR) | |||
| 3 | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A, B: 172 - 322 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Ser 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34817.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1193.3 | |
| All* | Total formula weight | 36011.0 |
