PDB: 86 resultsInfo pagesStatus searchChemie searchBIRD

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3S8A	Structure of Yeast Ribonucleotide Reductase R293A with dGTP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8B	Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8C	Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3TB9	Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-08-05 Release date: 2012-04-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3TBA	Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. Deposit date: 2011-08-05 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3UUS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, FE (III) ION, Ribonucleoside-diphosphate reductase 1 subunit alpha, ... Authors: Zimanyi, C.M, Drennan, C.L. Deposit date: 2011-11-28 Release date: 2011-12-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (5.65 Å) Cite: Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proc.Natl.Acad.Sci.USA, 108, 2011
4ERM	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Zimanyi, C.M, Drennan, C.L. Deposit date: 2012-04-20 Release date: 2012-07-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.95 Å) Cite: Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure, 20, 2012
4ERP	Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 subunit alpha, ... Authors: Zimanyi, C.M, Drennan, C.L. Deposit date: 2012-04-20 Release date: 2012-07-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (4.45 Å) Cite: Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure, 20, 2012
4R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI Descriptor: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ... Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-22 Release date: 1998-01-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
4X3V	Crystal structure of human ribonucleotide reductase 1 bound to inhibitor Descriptor: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE Authors: Dealwis, C.G, Ahmad, M.F, Alam, I. Deposit date: 2014-12-01 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58, 2015
5CNS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, ... Authors: Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. Deposit date: 2015-07-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.975 Å) Cite: Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNT	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ... Authors: Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. Deposit date: 2015-07-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNU	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution Descriptor: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. Deposit date: 2015-07-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNV	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution Descriptor: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. Deposit date: 2015-07-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5D1Y	Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP Descriptor: Ribonucleoside-diphosphate reductase large subunit Authors: Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. Deposit date: 2015-08-04 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (9.005 Å) Cite: Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry, 55, 2016
5IM3	Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase Authors: Johansson, R, Logan, D.T. Deposit date: 2016-03-05 Release date: 2016-05-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.298 Å) Cite: Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones. Structure, 24, 2016
5R1R	RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-09-17 Release date: 1998-03-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
5TUS	Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule Descriptor: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... Authors: Mohammed, F.A, Alam, I, Dealwis, C.G. Deposit date: 2016-11-07 Release date: 2017-08-02 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AUI	Human ribonucleotide reductase large subunit (alpha) with dATP and CDP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. Deposit date: 2017-09-01 Release date: 2018-04-18 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
6CGL	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4) Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION Authors: Maggiolo, A.O, Boal, A.K. Deposit date: 2018-02-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.2 Å) Cite: An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGM	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free) Descriptor: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase Authors: Maggiolo, A.O, Boal, A.K. Deposit date: 2018-02-20 Release date: 2018-05-09 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... Authors: Maggiolo, A.O, Boal, A.K. Deposit date: 2018-02-20 Release date: 2018-05-09 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6L3R	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide Descriptor: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ... Authors: Miyahara, S, Chong, K.T, Suzuki, T. Deposit date: 2019-10-15 Release date: 2020-10-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6L7L	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide Descriptor: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ... Authors: Miyahara, S, Chong, K.T, Suzuki, T. Deposit date: 2019-11-01 Release date: 2020-11-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.171 Å) Cite: TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6LKM	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide Descriptor: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... Authors: Miyahara, S, Chong, K.T, Suzuki, T. Deposit date: 2019-12-19 Release date: 2020-12-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.55 Å) Cite: TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published

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