5TUS

Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule

Summary for 5TUS

Entry DOI	10.2210/pdb5tus/pdb
Descriptor	Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	ribonucleotide reductase, small molecule inhibitor, active site inhibitor, competitive inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	181677.31
Authors	Mohammed, F.A.,Alam, I.,Dealwis, C.G. (deposition date: 2016-11-07, release date: 2017-08-02, Last modification date: 2020-01-01)
Primary citation	Ahmad, M.F.,Alam, I.,Huff, S.E.,Pink, J.,Flanagan, S.A.,Shewach, D.,Misko, T.A.,Oleinick, N.L.,Harte, W.E.,Viswanathan, R.,Harris, M.E.,Dealwis, C.G. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc. Natl. Acad. Sci. U.S.A., 114:8241-8246, 2017 Cited by PubMed: 28716944 DOI: 10.1073/pnas.1620220114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation