5TUS
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
Summary for 5TUS
Entry DOI | 10.2210/pdb5tus/pdb |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | ribonucleotide reductase, small molecule inhibitor, active site inhibitor, competitive inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 181677.31 |
Authors | Mohammed, F.A.,Alam, I.,Dealwis, C.G. (deposition date: 2016-11-07, release date: 2017-08-02, Last modification date: 2020-01-01) |
Primary citation | Ahmad, M.F.,Alam, I.,Huff, S.E.,Pink, J.,Flanagan, S.A.,Shewach, D.,Misko, T.A.,Oleinick, N.L.,Harte, W.E.,Viswanathan, R.,Harris, M.E.,Dealwis, C.G. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc. Natl. Acad. Sci. U.S.A., 114:8241-8246, 2017 Cited by PubMed: 28716944DOI: 10.1073/pnas.1620220114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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