5CNU

Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution

Summary for 5CNU

• Entry DOI: 10.2210/pdb5cnu/pdb
• Related: 5CNS 5CNT 5CNV
• Descriptor: Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... (8 entities in total)
• Functional Keywords: allostery, substrate specificity, ribonucleotide reductase, nucleotide metabolism, oxidoreductase
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 8
• Total formula weight: 523303.33

Authors

Chen, P.Y.-T.,Zimanyi, C.M.,Funk, M.A.,Drennan, C.L. (deposition date: 2015-07-18, release date: 2016-01-20, Last modification date: 2023-09-27)

• Primary citation: Zimanyi, C.M.,Chen, P.Y.,Kang, G.,Funk, M.A.,Drennan, C.L.; Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.; Elife, 5:e07141-e07141, 2016; PubMed: 26754917; DOI: 10.7554/eLife.07141

Experimental method

X-RAY DIFFRACTION (3.4 Å)