6L3R
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
Summary for 6L3R
Entry DOI | 10.2210/pdb6l3r/pdb |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 154642.57 |
Authors | Miyahara, S.,Chong, K.T.,Suzuki, T. (deposition date: 2019-10-15, release date: 2020-10-28, Last modification date: 2023-11-22) |
Primary citation | Miyahara, S.,Hara, S.,Chong, K.T.,Suzuki, T.,Ogino, Y.,Hoshino, T.,Tsukioka, S.,Yano, W.,Suzuki, M.,Otsu, Y.,Yonekura, T.,Ito, S.,Terasaka, M.,Suzuki, T.,Hashimoto, A. TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)