6L3R
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, E) | Ribonucleoside-diphosphate reductase large subunit | polymer | 669 | 76189.9 | 2 | UniProt (P23921) Pfam (PF00317) Pfam (PF02867) | Homo sapiens (Human) | Ribonucleotide reductase R1 subunit |
| 2 | C, J (A, E) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 2 | Chemie (TTP) | |||
| 3 | D, H (A, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, I (A, E) | 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide | non-polymer | 488.4 | 2 | Chemie (E4X) | |||
| 5 | F, G, K (A, E) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | L (E) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | M, N (A, E) | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
A, E: 75 - 742 (UniProt: P23921)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 152379.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2262.8 | |
| All* | Total formula weight | 154642.6 |
