4ERP

Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex

Summary for 4ERP

Entry DOI	10.2210/pdb4erp/pdb
Related	4ERM
Descriptor	Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	protein-protein complex, alpha/beta barrel, atp cone, diiron center, oxidoreductase, rnr alpha, rnr beta, thioredoxin, ribonucleotide reduction, cytosol
Biological source	Escherichia coli K-12 More
Total number of polymer chains	8
Total formula weight	519755.28
Authors	Zimanyi, C.M.,Drennan, C.L. (deposition date: 2012-04-20, release date: 2012-07-04, Last modification date: 2023-09-13)
Primary citation	Zimanyi, C.M.,Ando, N.,Brignole, E.J.,Asturias, F.J.,Stubbe, J.,Drennan, C.L. Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure, 20:1374-1383, 2012 Cited by PubMed: 22727814 DOI: 10.1016/j.str.2012.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.45 Å)

Structure validation