6LKM

Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide

Summary for 6LKM

• Entry DOI: 10.2210/pdb6lkm/pdb
• Descriptor: Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 154414.60

Authors

Miyahara, S.,Chong, K.T.,Suzuki, T. (deposition date: 2019-12-19, release date: 2020-12-23, Last modification date: 2023-11-22)

• Primary citation: Miyahara, S.,Hara, S.,Chong, K.T.,Suzuki, T.,Ogino, Y.,Hoshino, T.,Tsukioka, S.,Yano, W.,Suzuki, M.,Otsu, Y.,Yonekura, T.,Ito, S.,Terasaka, M.,Suzuki, T.,Hashimoto, A.; TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity; To be published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)