6LKM
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide
Summary for 6LKM
Entry DOI | 10.2210/pdb6lkm/pdb |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 154414.60 |
Authors | Miyahara, S.,Chong, K.T.,Suzuki, T. (deposition date: 2019-12-19, release date: 2020-12-23, Last modification date: 2023-11-22) |
Primary citation | Miyahara, S.,Hara, S.,Chong, K.T.,Suzuki, T.,Ogino, Y.,Hoshino, T.,Tsukioka, S.,Yano, W.,Suzuki, M.,Otsu, Y.,Yonekura, T.,Ito, S.,Terasaka, M.,Suzuki, T.,Hashimoto, A. TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published, |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
Download full validation report