6LKM
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 801 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue TTP A 802 |
| Chain | Residue |
| A | SER269 |
| A | ASN270 |
| A | MG801 |
| B | LYS243 |
| B | TYR285 |
| B | VAL286 |
| B | ASP287 |
| B | GLY289 |
| A | ASP226 |
| A | SER227 |
| A | ILE228 |
| A | ILE255 |
| A | ARG256 |
| A | ILE262 |
| A | ALA263 |
| A | GLY264 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EJ6 A 803 |
| Chain | Residue |
| A | SER687 |
| A | GLN688 |
| A | LYS689 |
| A | LYS719 |
| A | SER722 |
| A | MET723 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 801 |
| Chain | Residue |
| B | TTP802 |
| B | HOH904 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue TTP B 802 |
| Chain | Residue |
| A | LYS243 |
| A | TYR285 |
| A | VAL286 |
| A | ASP287 |
| A | GLN288 |
| B | ASP226 |
| B | SER227 |
| B | ILE228 |
| B | ARG256 |
| B | ILE262 |
| B | ALA263 |
| B | GLY264 |
| B | THR265 |
| B | SER269 |
| B | ASN270 |
| B | MG801 |
| B | HOH904 |
| B | HOH907 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EJ6 B 803 |
| Chain | Residue |
| B | ILE686 |
| B | SER687 |
| B | GLN688 |
| B | LYS689 |
| B | LYS719 |
| B | MET723 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkvLkekiakyGIRNsllIApmP |
| Chain | Residue | Details |
| A | TRP581-PRO603 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Cysteine radical intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3HND","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3HNE","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for hydrogen atom transfer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for electron transfer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
