6LKM
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ribonucleoside-diphosphate reductase large subunit | polymer | 669 | 76189.9 | 2 | UniProt (P23921) Pfam (PF00317) Pfam (PF02867) | Homo sapiens (Human) | Ribonucleotide reductase R1 subunit |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 2 | Chemie (TTP) | |||
| 4 | E, H (A, B) | 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide | non-polymer | 511.0 | 2 | Chemie (EJ6) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A, B: 75 - 742 (UniProt: P23921)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 152379.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2034.9 | |
| All* | Total formula weight | 154414.6 |
