4X3V
Crystal structure of human ribonucleotide reductase 1 bound to inhibitor
Summary for 4X3V
Entry DOI | 10.2210/pdb4x3v/pdb |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine (3 entities in total) |
Functional Keywords | complex, reducatse, inhibitor, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 181740.83 |
Authors | Dealwis, C.G.,Ahmad, M.F.,Alam, I. (deposition date: 2014-12-01, release date: 2015-11-11, Last modification date: 2023-09-27) |
Primary citation | Ahmad, M.F.,Huff, S.E.,Pink, J.,Alam, I.,Zhang, A.,Perry, K.,Harris, M.E.,Misko, T.,Porwal, S.K.,Oleinick, N.L.,Miyagi, M.,Viswanathan, R.,Dealwis, C.G. Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58:9498-9509, 2015 Cited by PubMed: 26488902DOI: 10.1021/acs.jmedchem.5b00929 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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