PDB: 117 resultsInfo pagesStatus searchChemie searchBIRD

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5GUT	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... Authors: Chen, S.J, Ye, F. Deposit date: 2016-08-31 Release date: 2017-09-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
5GUV	The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Ye, F, Chen, S.J. Deposit date: 2016-08-31 Release date: 2017-08-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.078 Å) Cite: Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
5LOD	Crystal structure of HhaI DNA methyltransferase in APO form Descriptor: Modification methylase HhaI, SULFATE ION Authors: Rondelet, G, Wouters, J. Deposit date: 2016-08-09 Release date: 2017-08-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem, 9, 2017
5MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH HEMIMETHYLATED DNA AND ADOHCY Descriptor: DNA (5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ... Authors: Cheng, X. Deposit date: 1996-10-22 Release date: 1997-07-23 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. J.Mol.Biol., 263, 1996
5WY1	Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION Authors: Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. Deposit date: 2017-01-10 Release date: 2017-05-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 J. Biochem., 162, 2017
5YX2	Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Zhang, Z.M, Song, J. Deposit date: 2017-12-01 Release date: 2018-01-31 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.653 Å) Cite: Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
6BRR	Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Zhang, Z.M, Song, J. Deposit date: 2017-11-30 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
6F57	Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA Descriptor: DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*ZP*GP*CP*TP*CP*T)-3'), DNA (cytosine-5)-methyltransferase 3-like, ... Authors: Zhang, Z.M, Song, J. Deposit date: 2017-12-01 Release date: 2018-01-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.098 Å) Cite: Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
6FDF	Crystal structure of S. pombe Dnmt2 methyltransferase Descriptor: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase Authors: Johannsson, S, Neumann, P, Ficner, R. Deposit date: 2017-12-22 Release date: 2018-06-20 Method: X-RAY DIFFRACTION (1.697 Å) Cite: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Sci Rep, 8, 2018
6KDA	Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpG site Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-01 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.909 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDB	Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-01 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.862 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDL	Crystal structure of human DNMT3B-DNMT3L complex (I) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.274 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDP	Crystal structure of human DNMT3B-DNMT3L complex (II) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDT	Crystal structure of human DNMT3B (Q772R)-DNMT3L complex Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND DNA CONTAINING 4'-THIO-2'DEOXYCYTIDINE AT THE TARGET Descriptor: CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(4SC)P*GP*CP*AP*TP*GP*G)-3'), ... Authors: Cheng, X. Deposit date: 1998-08-05 Release date: 1998-08-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.05 Å) Cite: DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. Nucleic Acids Res., 25, 1997
6PA7	The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. Descriptor: CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ... Authors: Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A. Deposit date: 2019-06-11 Release date: 2020-06-17 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586, 2020
6U8P	Crystal structure of DNMT3B-DNMT3L in complex with CpGpA DNA Descriptor: CpGpA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-05 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U8V	Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Zhang, Z.M, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U8W	Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Zhang, Z.M, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.94891548 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U8X	Crystal structure of DNMT3B-DNMT3L in complex with CpApG DNA Descriptor: CpApG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.95063877 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U90	Crystal structure of DNMT3B(N779A)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.00081754 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
6U91	Crystal structure of DNMT3B(Q772R)-DNMT3L in complex with CpGpT DNA Descriptor: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Gao, L, Song, J. Deposit date: 2019-09-06 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.99998879 Å) Cite: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
6W89	Structure of DNMT3A (R882H) in complex with CGA DNA Descriptor: CGA DNA (25-MER), CITRIC ACID, DNA (cytosine-5)-methyltransferase 3-like, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8B	Structure of DNMT3A in complex with CGA DNA Descriptor: CGA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8D	Structure of DNMT3A (R882H) in complex with CGT DNA Descriptor: CGT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.598 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020

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