6U8P

Crystal structure of DNMT3B-DNMT3L in complex with CpGpA DNA

Summary for 6U8P

• Entry DOI: 10.2210/pdb6u8p/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5)-methyltransferase 3-like, CpGpA DNA (25-MER), ... (6 entities in total)
• Functional Keywords: dnmt3b, dnmt3l, dna methylation, methyltransferase, transferase-dna complex, transferase, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 130915.61

Authors

Gao, L.,Song, J. (deposition date: 2019-09-05, release date: 2020-06-10, Last modification date: 2023-10-11)

• Primary citation: Gao, L.,Emperle, M.,Guo, Y.,Grimm, S.A.,Ren, W.,Adam, S.,Uryu, H.,Zhang, Z.M.,Chen, D.,Yin, J.,Dukatz, M.,Anteneh, H.,Jurkowska, R.Z.,Lu, J.,Wang, Y.,Bashtrykov, P.,Wade, P.A.,Wang, G.G.,Jeltsch, A.,Song, J.; Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.; Nat Commun, 11:3355-3355, 2020; PubMed: 32620778; DOI: 10.1038/s41467-020-17109-4

Experimental method

X-RAY DIFFRACTION (3.05 Å)