5LOD

Crystal structure of HhaI DNA methyltransferase in APO form

Summary for 5LOD

Entry DOI	10.2210/pdb5lod/pdb
Descriptor	Modification methylase HhaI, SULFATE ION (3 entities in total)
Functional Keywords	m.hhai, c5-methylcytosine, apo form, dna methyltransferase, transferase
Biological source	Haemophilus parahaemolyticus
Total number of polymer chains	2
Total formula weight	74564.73
Authors	Rondelet, G.,Wouters, J. (deposition date: 2016-08-09, release date: 2017-08-16, Last modification date: 2024-01-10)
Primary citation	Rondelet, G.,Fleury, L.,Faux, C.,Masson, V.,Dubois, J.,Arimondo, P.B.,Willems, L.,Wouters, J. Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem, 9:1465-1481, 2017 Cited by PubMed Abstract: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in cancer cells and mode of action of these compounds remains unclear. PubMed: 28795598 DOI: 10.4155/fmc-2017-0074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation