6W8D

Structure of DNMT3A (R882H) in complex with CGT DNA

Summary for 6W8D

• Entry DOI: 10.2210/pdb6w8d/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, CGT DNA (25-MER), ... (5 entities in total)
• Functional Keywords: dna methylation, dnmt3a(r882h), aml, epigenetics, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 129887.51

Authors

Anteneh, H.,Song, J. (deposition date: 2020-03-20, release date: 2020-04-15, Last modification date: 2023-10-18)

• Primary citation: Anteneh, H.,Fang, J.,Song, J.; Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.; Nat Commun, 11:2294-2294, 2020; PubMed: 32385248; DOI: 10.1038/s41467-020-16213-9

Experimental method

X-RAY DIFFRACTION (2.598 Å)