6F57

Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA

Summary for 6F57

• Entry DOI: 10.2210/pdb6f57/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3'), ... (5 entities in total)
• Functional Keywords: dnmt3a, dnmt3l, dna methylation, dna binding protein, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9Y6K1 Q9UJW3
• Total number of polymer chains: 8
• Total formula weight: 127256.02

Authors

Zhang, Z.M.,Song, J. (deposition date: 2017-12-01, release date: 2018-01-31, Last modification date: 2024-01-17)

• Primary citation: Zhang, Z.M.,Lu, R.,Wang, P.,Yu, Y.,Chen, D.,Gao, L.,Liu, S.,Ji, D.,Rothbart, S.B.,Wang, Y.,Wang, G.G.,Song, J.; Structural basis for DNMT3A-mediated de novo DNA methylation.; Nature, 554:387-391, 2018; PubMed: 29414941; DOI: 10.1038/nature25477

Experimental method

X-RAY DIFFRACTION (3.098 Å)