6F57

Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	DNA (cytosine-5)-methyltransferase 3A	polymer	285	32715.7	2	UniProt (Q9Y6K1) Pfam (PF00145)	Homo sapiens (Human)	Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA
2	B, C (B, C)	DNA (cytosine-5)-methyltransferase 3-like	polymer	209	24163.7	2	UniProt (Q9UJW3)	Homo sapiens (Human)
3	E, G (E, G)	DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3')	polymer	10	3094.0	2		Homo sapiens
4	F, H (F, H)	DNA (5'-D(*CP*AP*TP*GP*ZP*GP*CP*TP*CP*T)-3')	polymer	11	3270.1	2		Homo sapiens
5	I, J (A, D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	126487.2
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	127256.0

*Water molecules are not included.