4ZK3
 
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3Q02
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3PZF
 | | 1.75A resolution structure of Serpin-2 from Anopheles gambiae | | 分子名称: | Serpin 2 | | 著者 | Lovell, S, Battaile, K.P, An, C, Michel, K. | | 登録日 | 2010-12-14 | | 公開日 | 2011-02-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes.
Proteins, 79, 2011
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3Q03
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2ZNH
 | | Crystal Structure of a Domain-Swapped Serpin Dimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... | | 著者 | Yamasaki, M, Huntington, J.A. | | 登録日 | 2008-04-25 | | 公開日 | 2008-10-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Nature, 455, 2008
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2ZV6
 | | Crystal structure of human squamous cell carcinoma antigen 1 | | 分子名称: | Serpin B3 | | 著者 | Zheng, B, Matoba, Y, Katagiri, C, Hibino, T, Sugiyama, M. | | 登録日 | 2008-11-01 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of SCCA1 and insight about the interaction with JNK1
Biochem.Biophys.Res.Commun., 380, 2009
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3R4L
 | | Human very long half life Plasminogen Activator Inhibitor type-1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasminogen activator inhibitor 1, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Yang, J, Zheng, H, Han, Q, Skrzypczak-Jankun, E, Jankun, J. | | 登録日 | 2011-03-17 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.
Int.J.Mol.Med., 29, 2012
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3T1P
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3STO
 | | Serpin from the trematode Schistosoma Haematobium | | 分子名称: | Serine protease inhibitor | | 著者 | Granzin, J, Weiergraeber, O.H, Lee, X, Blanton, R.E. | | 登録日 | 2011-07-11 | | 公開日 | 2012-05-30 | | 最終更新日 | 2013-01-23 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.
Acta Crystallogr.,Sect.D, 68, 2012
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3CAA
 | | CLEAVED ANTICHYMOTRYPSIN A347R | | 分子名称: | ANTICHYMOTRYPSIN | | 著者 | Lukacs, C.M, Christianson, D.W. | | 登録日 | 1997-08-18 | | 公開日 | 1998-02-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
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3CVM
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3CWL
 | | Crystal structure of alpha-1-antitrypsin, crystal form B | | 分子名称: | Alpha-1-antitrypsin, CHLORIDE ION | | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | | 登録日 | 2008-04-22 | | 公開日 | 2008-09-23 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
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3CWM
 | | Crystal structure of alpha-1-antitrypsin complexed with citrate | | 分子名称: | Alpha-1-antitrypsin, CITRIC ACID | | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | | 登録日 | 2008-04-22 | | 公開日 | 2008-09-23 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
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3UT3
 | | A novel PAI-I inhibitor and its structural mechanism | | 分子名称: | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione, Plasminogen activator inhibitor 1 | | 著者 | Lin, Z.H, Hong, Z.B, Shi, X.L, Hu, L.H, Andreasen, P.A, Huang, M.D. | | 登録日 | 2011-11-25 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | A novel PAI-I inhibitor and its structural mechanism
To be Published
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4P0O
 | | Cleaved Serpin 42Da | | 分子名称: | Serine protease inhibitor 4, isoform B | | 著者 | Ellisdon, A.M, Whisstock, J.C. | | 登録日 | 2014-02-21 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
Bmc Struct.Biol., 14, 2014
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4P0F
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4DY0
 | | Crystal structure of native protease nexin-1 with heparin | | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ... | | 著者 | Huntington, J.A, Li, W. | | 登録日 | 2012-02-28 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
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4DTE
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6ZRV
 | | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93) | | 分子名称: | Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) | | 著者 | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | | 登録日 | 2020-07-15 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Int J Mol Sci, 21, 2020
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4EB1
 | | Hyperstable in-frame insertion variant of antithrombin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III | | 著者 | Martinez-Martinez, I, Johnson, D.J.D, Yamasaki, M, Corral, J, Huntington, J.A. | | 登録日 | 2012-03-23 | | 公開日 | 2012-07-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
J.Thromb.Haemost., 10, 2012
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4PYW
 | | 1.92 angstrom crystal structure of A1AT:TTAI ternary complex | | 分子名称: | ACE-THR-THR-ALA-ILE-NH2, Alpha-1-antitrypsin, GLYCEROL | | 著者 | Nyon, M.P, Day, J, Gooptu, B. | | 登録日 | 2014-03-28 | | 公開日 | 2015-06-10 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of alpha 1 -antitrypsin upon ligand binding.
Protein Sci., 24, 2015
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7API
 | | THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA 1-ANTITRYPSIN, ... | | 著者 | Loebermann, H, Tokuoka, R, Deisenhofer, J, Huber, R. | | 登録日 | 1988-09-08 | | 公開日 | 1990-10-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
Protein Eng., 2, 1989
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7AQF
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7AQG
 | | Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) | | 分子名称: | 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), ... | | 著者 | Sillen, M, Strelkov, S.V, Declerck, P.J. | | 登録日 | 2020-10-21 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22, 2021
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7AEL
 | | alpha 1-antitrypsin (C232S) complexed with GSK716 | | 分子名称: | Alpha-1-antitrypsin, SULFATE ION, ~{N}-[(1~{S},2~{R})-1-(3-fluoranyl-2-methyl-phenyl)-1-oxidanyl-pentan-2-yl]-2-oxidanylidene-1,3-dihydroindole-4-carboxamide | | 著者 | Chung, C. | | 登録日 | 2020-09-17 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Development of a small molecule that corrects misfolding and increases secretion of Z alpha 1 -antitrypsin.
Embo Mol Med, 13, 2021
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