4P0F
Cleaved Serpin 42Da (C 2 2 21)
Summary for 4P0F
| Entry DOI | 10.2210/pdb4p0f/pdb |
| Descriptor | Serine protease inhibitor 4, isoform B (2 entities in total) |
| Functional Keywords | serpin 42da, serpin 4, serine protease inhibitor, neuroserpin, drosophila, hydrolase inhibitor |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Total number of polymer chains | 1 |
| Total formula weight | 44309.48 |
| Authors | Ellisdon, A.M.,Whisstock, J.C. (deposition date: 2014-02-21, release date: 2014-05-07, Last modification date: 2023-09-27) |
| Primary citation | Ellisdon, A.M.,Zhang, Q.,Henstridge, M.A.,Johnson, T.K.,Warr, C.G.,Law, R.H.,Whisstock, J.C. High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. Bmc Struct.Biol., 14:14-14, 2014 Cited by PubMed Abstract: The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reactive centre loop exons. Eight protein isoforms of Serpin 42 Da have been identified to date, targeting the protease inhibitor to both different proteases and cellular locations. Biochemical and genetic studies suggest that Serpin 42 Da inhibits target proteases through the classical serpin 'suicide' inhibition mechanism, however the crystal structure of a representative Serpin 42 Da isoform remains to be determined. PubMed: 24758516DOI: 10.1186/1472-6807-14-14 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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