3CWL

Crystal structure of alpha-1-antitrypsin, crystal form B

Summary for 3CWL

Entry DOI	10.2210/pdb3cwl/pdb
Related	3CWM
Descriptor	Alpha-1-antitrypsin, CHLORIDE ION (3 entities in total)
Functional Keywords	antitrypsin, polymerisation, protein aggregation, protein unfolding, serpin, acute phase, disease mutation, glycoprotein, protease inhbitor, secreted, serine protease inhibitor, blood coagulation, protease inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
Total number of polymer chains	1
Total formula weight	44445.81
Authors	Morton, C.J.,Hansen, G.,Feil, S.C.,Adams, J.J.,Parker, M.W. (deposition date: 2008-04-22, release date: 2008-09-23, Last modification date: 2017-10-25)
Primary citation	Pearce, M.C.,Morton, C.J.,Feil, S.C.,Hansen, G.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17:2127-2133, 2008 Cited by PubMed: 18780818 DOI: 10.1110/ps.037234.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation