3CWM
Crystal structure of alpha-1-antitrypsin complexed with citrate
Summary for 3CWM
Entry DOI | 10.2210/pdb3cwm/pdb |
Related | 3CWL |
Descriptor | Alpha-1-antitrypsin, CITRIC ACID (3 entities in total) |
Functional Keywords | antitrypsin, polymerisation, protein aggregation, protein unfolding, serpin, acute phase, disease mutation, glycoprotein, protease inhbitor, secreted, serine protease inhibitor, blood coagulation, protease inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 |
Total number of polymer chains | 1 |
Total formula weight | 44602.48 |
Authors | Morton, C.J.,Hansen, G.,Feil, S.C.,Adams, J.J.,Parker, M.W. (deposition date: 2008-04-22, release date: 2008-09-23, Last modification date: 2017-10-25) |
Primary citation | Pearce, M.C.,Morton, C.J.,Feil, S.C.,Hansen, G.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17:2127-2133, 2008 Cited by PubMed: 18780818DOI: 10.1110/ps.037234.108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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