PDB: 657 件ウェブページステータス検索Chemie searchBIRD

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3UA8	Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2 分子名称: Glutamate receptor 2, N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide 著者 Kallen, J. 登録日 2011-10-21 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists. Bioorg.Med.Chem.Lett., 22, 2012
3TKD	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution 分子名称: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... 著者 Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-08-26 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
3U92	Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
3TZA	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution 分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, Glutamate receptor 2,Glutamate receptor 2, SULFATE ION 著者 Frydenvang, K, Kastrup, J.S. 登録日 2011-09-27 公開日 2011-10-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure J.Med.Chem., 54, 2011
3U94	Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P21212 form 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.962 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
3U93	Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P2221 form 分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... 著者 Kumar, J, Mayer, M.L. 登録日 2011-10-17 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.881 Å) 主引用文献 Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron, 76, 2012
4O3A	Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3B	Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution 分子名称: ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3C	Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
5FHM	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution 分子名称: (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Kastrup, J.S, Frydenvang, K, Al-musaed, A. 登録日 2015-12-22 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
5FHN	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution 分子名称: (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2015-12-22 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
5FXH	GluN1b-GluN2B NMDA receptor in non-active-1 conformation 分子名称: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. 登録日 2016-03-02 公開日 2016-05-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5FTH	Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ZINC ION 著者 Nayeem, N, Green, T. 登録日 2016-01-13 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes. Neuron, 89, 2016
5FTI	Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, GLYCEROL, ... 著者 Nayeem, N, Green, T. 登録日 2016-01-13 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes. Neuron, 89, 2016
4PE5	Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... 著者 Karakas, E, Furukawa, H. 登録日 2014-04-22 公開日 2014-06-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.96 Å) 主引用文献 Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
5H8H	Structure of the human GluN1/GluN2A LBD in complex with GNE3419 分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ACETATE ION, CALCIUM ION, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8F	Structure of the apo human GluN1/GluN2A LBD 分子名称: GLUTAMIC ACID, GLYCEROL, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8S	Structure of the human GluA2 LBD in complex with GNE3419 分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, CACODYLATE ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8Q	Structure of the human GluN1/GluN2A LBD in complex with GNE8324 分子名称: 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one, ACETATE ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8N	Structure of the human GluN1/GluN2A LBD in complex with NAM 分子名称: 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide, CALCIUM ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
4Q30	Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2014-04-10 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53, 2014
5I59	Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 分子名称: 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Mou, T.-C, Sprang, S.R, Hansen, K.B. 登録日 2016-02-14 公開日 2016-09-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
5I2K	Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19) 分子名称: 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2016-02-09 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016
5IOU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation 分子名称: GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ... 著者 Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. 登録日 2016-03-09 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5IPU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a 著者 Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. 登録日 2016-03-09 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (15.4 Å) 主引用文献 Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016

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