4Q30
Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5
Summary for 4Q30
| Entry DOI | 10.2210/pdb4q30/pdb |
| Related | 3RTW |
| Descriptor | Glutamate receptor 2 CHIMERIC PROTEIN, 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, ZINC ION, ... (4 entities in total) |
| Functional Keywords | glutamate receptor, glua2, glur2, ampa receptor, lbd, neurotransmitter receptor, nitrowillardiine, transport protein |
| Biological source | Rattus norvegicus (brown rat,rat,rats) More |
| Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
| Total number of polymer chains | 3 |
| Total formula weight | 87481.46 |
| Authors | Ahmed, A.H.,Oswald, R.E. (deposition date: 2014-04-10, release date: 2014-06-04, Last modification date: 2023-09-20) |
| Primary citation | Martinez, M.,Ahmed, A.H.,Loh, A.P.,Oswald, R.E. Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53:3790-3795, 2014 Cited by PubMed: 24850223DOI: 10.1021/bi500511m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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