PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

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6QQ7	Bovine insulin at ambient pressure Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-18 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6HN5	Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... Authors: Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. Deposit date: 2018-09-14 Release date: 2018-11-21 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
6FF3	Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I Descriptor: Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 Authors: Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. Deposit date: 2018-01-03 Release date: 2018-09-26 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6FEY	Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin Descriptor: Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 Authors: Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. Deposit date: 2018-01-03 Release date: 2018-09-26 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.48 Å) Cite: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6CK2	Insulin analog containing a YB26W mutation Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Rege, N.K, Yee, V.C, Weiss, M.A. Deposit date: 2018-02-27 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J. Biol. Chem., 293, 2018
6CE9	Insulin Receptor ectodomain in complex with two insulin molecules Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CEB	Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CE7	Insulin Receptor ectodomain in complex with one insulin molecule Descriptor: Insulin A chain, Insulin B chain, Insulin receptor, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
5U8Q	Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ... Authors: Lawrence, M, Xu, Y. Deposit date: 2016-12-14 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.2710402 Å) Cite: How ligand binds to the type 1 insulin-like growth factor receptor. Nat Commun, 9, 2018
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5UQA	Insulin with proline analog FzP at position B28 in the R6 state Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-07 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.31000245 Å) Cite: Insulin with proline analog FzP at position B28 in the R6 state To Be Published
5UU3	Insulin with proline analog DfP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin, chain A, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Insulin with proline analog DfP at position B28 in the R6 state To Be Published
5MWQ	Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2017-01-19 Release date: 2018-02-14 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Lysine mis-incorporation at asparagine position during recombinant proteins production in E. coli To Be Published
5URT	Insulin with proline analog DhP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-12 Release date: 2018-02-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Insulin with proline analog DhP at position B28 in the T2 state To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
6BFC	Cryo-EM structure of human insulin degrading enzyme in complex with insulin Descriptor: Insulin, Insulin-degrading enzyme Authors: Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. Deposit date: 2017-10-26 Release date: 2017-12-27 Last modified: 2021-04-28 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6B70	Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin Descriptor: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... Authors: Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. Deposit date: 2017-10-03 Release date: 2017-12-27 Last modified: 2021-04-28 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5T7R	A6-A11 trans-dicarba human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. Deposit date: 2016-09-05 Release date: 2017-12-06 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin Descriptor: Insulin, Insulin-degrading enzyme Authors: Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. Deposit date: 2017-09-22 Release date: 2017-11-22 Last modified: 2021-04-28 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018

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