PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

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5KQV	Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... Authors: Lawrence, M.C, Smith, B.J, Croll, T.I. Deposit date: 2016-07-06 Release date: 2017-07-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.4 Å) Cite: How insulin engages its primary binding site on the insulin receptor. Nature, 493, 2013
5LIS	Insulin solved by Native SAD from a dataset collected in one second Descriptor: Insulin Authors: Casanas, A, Finke, A, Wang, M. Deposit date: 2016-07-15 Release date: 2016-08-03 Last modified: 2016-09-28 Method: X-RAY DIFFRACTION (2.293 Å) Cite: EIGER detector: application in macromolecular crystallography. Acta Crystallogr D Struct Biol, 72, 2016
5T7R	A6-A11 trans-dicarba human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. Deposit date: 2016-09-05 Release date: 2017-12-06 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
5MAM	Human insulin in complex with serotonin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2016-11-03 Release date: 2017-04-05 Last modified: 2017-05-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MHD	Biosynthetic engineered A22S-B3K-B31R human insulin monomer structure in water/acetonitrile solutions. Descriptor: Insulin Authors: Bocian, W, Kozerski, L, Bednarek, E, Sitkowski, J. Deposit date: 2016-11-24 Release date: 2017-08-09 Last modified: 2019-05-08 Method: SOLUTION NMR Cite: Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. J Pharm Biomed Anal, 135, 2017
5MIZ	MD ensemble of bovine insulin Descriptor: Insulin Authors: Efimov, S.V, Zgadzay, Y.O, Klochkov, V.V. Deposit date: 2016-11-29 Release date: 2017-01-25 Last modified: 2019-05-08 Method: SOLUTION NMR Cite: MD ensemble of bovine insulin To Be Published
5U8Q	Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ... Authors: Lawrence, M, Xu, Y. Deposit date: 2016-12-14 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.2710402 Å) Cite: How ligand binds to the type 1 insulin-like growth factor receptor. Nat Commun, 9, 2018
5UDP	High resolution x-ray crystal structure of synthetic insulin lispro Descriptor: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ... Authors: Mandal, K, Dhayalan, B, Kent, S.B.H. Deposit date: 2016-12-28 Release date: 2017-01-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.348 Å) Cite: Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017
5MT3	Human insulin in complex with serotonin and arginine Descriptor: ARGININE, CHLORIDE ION, Insulin, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2017-01-06 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MT9	Human insulin in complex with serotonin and arginine Descriptor: ARGININE, CHLORIDE ION, Insulin, ... Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2017-01-07 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
5MWQ	Biosynthetic engineered A21K-B31K-B32R human insulin monomer structure in water/acetonitrile solution Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2017-01-19 Release date: 2018-02-14 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Lysine mis-incorporation at asparagine position during recombinant proteins production in E. coli To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
5UQA	Insulin with proline analog FzP at position B28 in the R6 state Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-07 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.31000245 Å) Cite: Insulin with proline analog FzP at position B28 in the R6 state To Be Published
5URT	Insulin with proline analog DhP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-12 Release date: 2018-02-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Insulin with proline analog DhP at position B28 in the T2 state To Be Published
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5UU3	Insulin with proline analog DfP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin, chain A, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Insulin with proline analog DfP at position B28 in the R6 state To Be Published
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin Descriptor: Insulin, Insulin-degrading enzyme Authors: Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. Deposit date: 2017-09-22 Release date: 2017-11-22 Last modified: 2021-04-28 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018

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