1H02
 
 | | Human Insulin-like growth factor; SRS Daresbury data | | Descriptor: | INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE | | Authors: | Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. | | Deposit date: | 2002-06-11 | | Release date: | 2002-07-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
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1HIT
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1HIQ
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1HUI
 | | INSULIN MUTANT (B1, B10, B16, B27)GLU, DES-B30, NMR, 25 STRUCTURES | | Descriptor: | INSULIN | | Authors: | Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C. | | Deposit date: | 1996-03-29 | | Release date: | 1997-03-12 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an engineered insulin monomer at neutral pH.
Biochemistry, 35, 1996
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1HLS
 | | NMR STRUCTURE OF THE HUMAN INSULIN-HIS(B16) | | Descriptor: | INSULIN | | Authors: | Ludvigsen, S, Kaarsholm, N.C. | | Deposit date: | 1995-06-28 | | Release date: | 1995-09-15 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 33, 1994
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1HO0
 | | NEW B-CHAIN MUTANT OF BOVINE INSULIN | | Descriptor: | INSULIN | | Authors: | Dupradeau, F.Y, Richard, T, Le Flem, G, Oulyadi, H, Prigent, Y, Monti, J.P. | | Deposit date: | 2000-12-08 | | Release date: | 2000-12-20 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A new B-chain mutant of insulin: comparison with the insulin crystal structure and role of sulfonate groups in the B-chain structure
J.Pept.Res., 60, 2002
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1IZA
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1IGL
 | | SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS | | Descriptor: | INSULIN-LIKE GROWTH FACTOR II | | Authors: | Torres, A.M, Forbes, B.E, Aplin, S.E, Wallace, J.C, Francis, G.L, Norton, R.S. | | Deposit date: | 1994-12-29 | | Release date: | 1995-02-14 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions.
J.Mol.Biol., 248, 1995
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1IOH
 | | INSULIN MUTANT A8 HIS,(B1, B10, B16, B27)GLU, DES-B30, NMR, 26 STRUCTURES | | Descriptor: | PROTEIN (INSULIN PRECURSOR) | | Authors: | Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C. | | Deposit date: | 1998-08-13 | | Release date: | 1999-01-13 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
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1IZB
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1IOG
 | | INSULIN MUTANT A3 GLY,(B1, B10, B16, B27)GLU, DES-B30, NMR, 19 STRUCTURES | | Descriptor: | PROTEIN (INSULIN PRECURSOR) | | Authors: | Olsen, H.B, Ludvigsen, S, Kaarsholm, N.C. | | Deposit date: | 1998-08-13 | | Release date: | 1999-01-13 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
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1J73
 | | Crystal structure of an unstable insulin analog with native activity. | | Descriptor: | ZINC ION, insulin a, insulin b | | Authors: | Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A. | | Deposit date: | 2001-05-15 | | Release date: | 2001-05-30 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
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1IMX
 | | 1.8 Angstrom crystal structure of IGF-1 | | Descriptor: | BROMIDE ION, Insulin-like Growth Factor 1A, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE | | Authors: | Vajdos, F.F, Ultsch, M, Schaffer, M.L, Deshayes, K.D, Liu, J, Skelton, N.J, de Vos, A.M. | | Deposit date: | 2001-05-11 | | Release date: | 2001-09-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Biochemistry, 40, 2001
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1JCO
 | | Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin) | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Keller, D, Clausen, R, Josefsen, K, Led, J.J. | | Deposit date: | 2001-06-11 | | Release date: | 2001-10-03 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity.
Biochemistry, 40, 2001
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4BS3
 | | Bovin insulin structure determined by in situ crystal analysis and sulfur-SAD phasing at room temperature | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Pinker, F, Stirnimann, C, Sauter, C, Olieric, V. | | Deposit date: | 2013-06-06 | | Release date: | 2013-07-17 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Chipx: A Novel Microfluidic Chip for Counter- Diffusion Crystallization of Biomolecules and in Situ Crystal Analysis at Room Temperature
J.Cryst.Growth, 13, 2013
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2HH4
 | | NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | | Descriptor: | insulin A chain, insulin B chain | | Authors: | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | | Deposit date: | 2006-06-27 | | Release date: | 2006-07-18 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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2HHO
 | | NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | | Deposit date: | 2006-06-28 | | Release date: | 2006-07-18 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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2INS
 | | THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN | | Descriptor: | DES-PHE B1 INSULIN (CHAIN A), DES-PHE B1 INSULIN (CHAIN B), ZINC ION | | Authors: | Smith, G.D, Duax, W.L, Dodson, E.J, Dodson, G.G, Degraaf, R.A.G, Reynolds, C.D. | | Deposit date: | 1982-05-10 | | Release date: | 1982-08-05 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Structure of Des-Phe B1 Bovine Insulin
Acta Crystallogr.,Sect.B, 38, 1982
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4CXL
 | | Human insulin analogue (D-ProB8)-insulin | | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | | Deposit date: | 2014-04-07 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
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4CXN
 | | Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | | Deposit date: | 2014-04-07 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
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4CY7
 | | Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II | | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | | Deposit date: | 2014-04-10 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
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2JMN
 | | NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2006-11-21 | | Release date: | 2006-12-05 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
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2JV1
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2JUU
 | | allo-ThrA3 DKP-insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2007-09-03 | | Release date: | 2007-10-16 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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2JUM
 | | ThrA3-DKP-insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2007-08-31 | | Release date: | 2007-10-16 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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