1IOH

INSULIN MUTANT A8 HIS,(B1, B10, B16, B27)GLU, DES-B30, NMR, 26 STRUCTURES

Summary for 1IOH

DescriptorPROTEIN (INSULIN PRECURSOR) (2 entities in total)
Functional Keywordshormone, human insulin mutant, monomer, neutral ph, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5720.45
Authors
Olsen, H.B.,Ludvigsen, S.,Kaarsholm, N.C. (deposition date: 1998-08-13, release date: 1999-01-13, Last modification date: 2017-11-29)
Primary citation
Olsen, H.B.,Ludvigsen, S.,Kaarsholm, N.C.
The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284:477-488, 1998
PubMed: 9813131 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1998.2175
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers486.3%26.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures