PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

---

5BOQ	Human insulin with intra-chain chemical crosslink between modified B24 and B29 Descriptor: Insulin, SULFATE ION Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2015-05-27 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
3INC	Crystal structure of human insulin with Ni+2 complex Descriptor: Insulin A chain, Insulin B chain, NICKEL (II) ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-12 Release date: 2010-08-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
3INS	STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION Authors: Wlodawer, A, Savage, H. Deposit date: 1988-10-14 Release date: 1989-01-09 Last modified: 2017-11-29 Method: NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION Cite: Structure of insulin: results of joint neutron and X-ray refinement. Acta Crystallogr.,Sect.B, 45, 1989
3IR0	Crystal Structure of Human Insulin complexed with Cu+2 metal ion Descriptor: COPPER (II) ION, Insulin A chain, Insulin B chain Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Metal induced structural changes observed in Human insulin To be Published
3ILG	Crystal structure of humnan insulin Sr+2 complex Descriptor: Insulin A chain, Insulin B chain, STRONTIUM ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-07 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
6S4J	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin Descriptor: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] Authors: Johansson, E. Deposit date: 2019-06-28 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6S4I	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin Descriptor: Insulin, NITRATE ION Authors: Johansson, E. Deposit date: 2019-06-28 Release date: 2020-07-15 Last modified: 2020-08-12 Method: X-RAY DIFFRACTION (1.511 Å) Cite: Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6RVA	STRUCTURE OF [ASP58]-IGF-I ANALOGUE Descriptor: Insulin-like growth factor I Authors: Jiracek, J, Zakova, L, Socha, O. Deposit date: 2019-05-31 Release date: 2019-10-02 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J.Biol.Chem., 294, 2019
5AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE Descriptor: PHENOL, PROTEIN (INSULIN) Authors: O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. Deposit date: 1998-12-29 Release date: 2000-02-28 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
6QRH	High pressure structure of bovine insulin (100 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-19 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.152 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6QRK	High pressure structure of bovine insulin (200 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-19 Release date: 2019-03-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5CO6	Crystal structure of human zinc insulin at pH 6.5 Descriptor: CHLORIDE ION, Insulin, MAGNESIUM ION, ... Authors: Lima, L.M.T.R, PALMIERI, L.C. Deposit date: 2015-07-19 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of human zinc insulin at pH 6.5 To Be Published
6QQG	High pressure structure of bovine insulin (60 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-18 Release date: 2019-03-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.149 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5AZZ	Crystal structure of seleno-insulin Descriptor: Insulin A chain, Insulin B chain Authors: Watanabe, S, Okumura, M, Arai, K, Takei, T, Asahina, Y, Hojo, H, Iwaoka, M, Inaba, K. Deposit date: 2015-10-23 Release date: 2017-05-03 Last modified: 2017-06-14 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. Angew. Chem. Int. Ed. Engl., 56, 2017
6S34	Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Descriptor: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain Authors: Johansson, E. Deposit date: 2019-06-24 Release date: 2019-07-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Not Published
5CO2	Crystalization of human zinc insulin at pH 5.5 Descriptor: CHLORIDE ION, Insulin, ZINC ION Authors: Lima, L.M.T.R, Palmieri, L.C. Deposit date: 2015-07-19 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human zinc insulin at pH 5.5 To Be Published
5BPO	Human insulin with intra-chain chemical crosslink between modified B27 and B29 Descriptor: Insulin Authors: Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. Deposit date: 2015-05-28 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
6QQ7	Bovine insulin at ambient pressure Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-18 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
5CNY	Crystal Structure of human zinc insulin at pH 5.5 Descriptor: CHLORIDE ION, Insulin, ZINC ION Authors: Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2015-07-18 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of human zinc insulin at pH 5.5 To Be Published
5BTS	Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Norrman, M, Hjorth, C.F. Deposit date: 2015-06-03 Release date: 2016-03-09 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. J.Pharm.Sci., 105, 2016
3JSD	Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. Deposit date: 2009-09-10 Release date: 2010-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
5CO9	Crystal structure of human zinc insulin at pH 6.5 Descriptor: CHLORIDE ION, Insulin, ZINC ION Authors: Lima, L.M.T.R, Palmieri, L.C. Deposit date: 2015-07-20 Release date: 2015-08-26 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystal structure of human zinc insulin at pH 6.5 To Be Published
3GF1	SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY Descriptor: INSULIN-LIKE GROWTH FACTOR I Authors: Cooke, R.M, Harvey, T.S, Campbell, I.D. Deposit date: 1991-01-24 Release date: 1993-04-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30, 1991
1MHI	THREE-DIMENSIONAL SOLUTION STRUCTURE OF AN INSULIN DIMER. A STUDY OF THE B9(ASP) MUTANT OF HUMAN INSULIN USING NUCLEAR MAGNETIC RESONANCE DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS Descriptor: INSULIN Authors: Jorgensen, A.M.M, Kristensen, S.M, Led, J.J, Balschmidt, P. Deposit date: 1994-11-30 Release date: 1995-10-15 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. J.Mol.Biol., 227, 1992
1MPJ	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Descriptor: CHLORIDE ION, PHENOL, PHENOL INSULIN, ... Authors: Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. Deposit date: 1995-09-13 Release date: 1996-01-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995

<12345678910111213141516>