PDB: 266 件ウェブページステータス検索Chemie searchBIRD

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3AM7	Crystal structure of the ternary complex of eIF4E-M7GTP-4EBP2 peptide 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 2 著者 Tomoo, K, Fukuyo, A, In, Y, Ishida, T. 登録日 2010-08-17 公開日 2011-08-17 最終更新日 2023-04-12 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1. J.Pept.Sci., 17, 2011
3A61	Crystal structure of unphosphorylated p70S6K1 (Form II) 分子名称: Ribosomal protein S6 kinase beta-1, STAUROSPORINE 著者 Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. 登録日 2009-08-18 公開日 2009-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.43 Å) 主引用文献 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
3A62	Crystal structure of phosphorylated p70S6K1 分子名称: MANGANESE (II) ION, Ribosomal protein S6 kinase beta-1, STAUROSPORINE 著者 Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. 登録日 2009-08-18 公開日 2009-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
6JXA	Tel1 kinase compact monomer 分子名称: Serine/threonine-protein kinase TEL1 著者 Xin, J. 登録日 2019-04-23 公開日 2019-07-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Res., 29, 2019
6JXC	Tel1 kinase butterfly symmetric dimer 分子名称: Serine/threonine-protein kinase TEL1 著者 Xin, J. 登録日 2019-04-23 公開日 2019-07-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of allosteric regulation of Tel1/ATM kinase. Cell Res., 29, 2019
3CQW	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 分子名称: 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... 著者 Pandit, J. 登録日 2008-04-03 公開日 2008-05-27 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
3CQU	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 分子名称: Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, RAC-alpha serine/threonine-protein kinase 著者 Pandit, J. 登録日 2008-04-03 公開日 2008-05-27 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
7JWE	Gedatolisib bound to the PI3Kg catalytic subunit p110 gamma 分子名称: Gedatolisib, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Burke, J.E, Rathinaswamy, M.K, Harris, N.J. 登録日 2020-08-25 公開日 2021-03-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10, 2021
6E7F	Crystal Structure of Human Inositol Polyphosphate Multikinase (IPMK) Catalytic Core Domain 分子名称: Inositol polyphosphate multikinase, SULFATE ION 著者 Blind, R, Seacrist, C. 登録日 2018-07-26 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity. Sci Rep, 8, 2018
7LSW	Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP 分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION 著者 Appleton, B.A. 登録日 2021-02-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Sci Adv, 7, 2021
7LT6	Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP 分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein 著者 Appleton, B.A. 登録日 2021-02-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Sci Adv, 7, 2021
5D9G	Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide 分子名称: CHLORIDE ION, NICKEL (II) ION, PHOSPHATE ION, ... 著者 Scorsato, V, Sandy, J, Brandao-Neto, J, Pereira, H.M, Smetana, J.H.C, Aparicio, R. 登録日 2015-08-18 公開日 2016-08-10 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus. Sci Rep, 6, 2016
5DJ4	Leucine-bound Sestrin2 from Homo sapiens 分子名称: LEUCINE, Sestrin-2 著者 Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U. 登録日 2015-09-01 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.697 Å) 主引用文献 Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science, 351, 2016
6FO1	Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. 分子名称: ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... 著者 Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. 登録日 2018-02-05 公開日 2018-04-04 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
5FVM	Cryo electron microscopy of a complex of Tor and Lst8 分子名称: SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 著者 Baretic, D, Berndt, A, Ohashi, Y, Johnson, C.M, Williams, R.L. 登録日 2016-02-09 公開日 2016-04-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Tor Forms a Dimer Through an N-Terminal Helical Solenoid with a Complex Topology Nat.Commun., 7, 2016
5G5J	Crystal structure of human CYP3A4 bound to metformin 分子名称: CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I. 登録日 2016-05-25 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24, 2017
5GV2	Crystal structure of Arginine-bound CASTOR1 from Homo sapiens 分子名称: ARGININE, GATS-like protein 3, MAGNESIUM ION 著者 Gai, Z.C, Wu, G. 登録日 2016-09-01 公開日 2017-09-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway Cell Discov, 2, 2016
5T0N	Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution 分子名称: LEUCINE, Sestrin-2 著者 Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U. 登録日 2016-08-16 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.004 Å) 主引用文献 The apo-structure of the leucine sensor Sestrin2 is still elusive. Sci.Signal., 9, 2016
5I2C	Arginine-bound CASTOR1 from Homo sapiens 分子名称: ACETATE ION, ARGININE, GATS-like protein 3 著者 Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U. 登録日 2016-02-08 公開日 2016-08-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Nature, 536, 2016
5WKP	Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-25 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
5WLW	Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-27 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.317 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
8DKW	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-06 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKM	Cryo-EM structure of cystine-bound cystinosin in a lumen-open state 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin, ... 著者 Schmiege, P, Li, X. 登録日 2022-07-05 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKI	Cryo-EM structure of cystinosin in a lumen-open state 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-05 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKX	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5 分子名称: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin 著者 Schmiege, P, Li, X. 登録日 2022-07-06 公開日 2022-09-21 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022

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