5G5J

Crystal structure of human CYP3A4 bound to metformin

Summary for 5G5J

Entry DOI	10.2210/pdb5g5j/pdb
Descriptor	CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywords	oxidoreductase, monooxygenase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P08684
Total number of polymer chains	1
Total formula weight	56503.46
Authors	Sevrioukova, I. (deposition date: 2016-05-25, release date: 2017-06-07, Last modification date: 2024-01-10)
Primary citation	Guo, Z.,Sevrioukova, I.F.,Denisov, I.G.,Zhang, X.,Chiu, T.L.,Thomas, D.G.,Hanse, E.A.,Cuellar, R.A.D.,Grinkova, Y.V.,Langenfeld, V.W.,Swedien, D.S.,Stamschror, J.D.,Alvarez, J.,Luna, F.,Galvan, A.,Bae, Y.K.,Wulfkuhle, J.D.,Gallagher, R.I.,Petricoin, E.F.,Norris, B.,Flory, C.M.,Schumacher, R.J.,O'Sullivan, M.G.,Cao, Q.,Chu, H.,Lipscomb, J.D.,Atkins, W.M.,Gupta, K.,Kelekar, A.,Blair, I.A.,Capdevila, J.H.,Falck, J.R.,Sligar, S.G.,Poulos, T.L.,Georg, G.I.,Ambrose, E.,Potter, D.A. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24:1259-1275.e6, 2017 Cited by PubMed: 28919040 DOI: 10.1016/j.chembiol.2017.08.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation