Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor

Summary for 3CQW

DescriptorRAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordskinase, apoptosis, atp-binding, carbohydrate metabolism, cytoplasm, glucose metabolism, glycogen biosynthesis, glycogen metabolism, membrane, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, sugar transport, transferase, translation regulation, transport, alternative splicing, wnt signaling pathway
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P31749 P49841
Total number of polymer chains2
Total molecular weight41060.96
Pandit, J. (deposition date: 2008-04-03, release date: 2008-05-27, Last modification date: 2011-07-13)
Primary citation
Lippa, B.,Pan, G.,Corbett, M.,Li, C.,Kauffman, G.S.,Pandit, J.,Robinson, S.,Wei, L.,Kozina, E.,Marr, E.S.,Borzillo, G.,Knauth, E.,Barbacci-Tobin, E.G.,Vincent, P.,Troutman, M.,Baker, D.,Rajamohan, F.,Kakar, S.,Clark, T.,Morris, J.
Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18:3359-3363, 2008
PubMed: 18456494 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2008.04.034
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26640 4.2% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21