3CQW
Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RAC-alpha serine/threonine-protein kinase | polymer | 342 | 39608.1 | 1 | UniProt (P31749) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (human) | RAC-PK-alpha, Protein kinase B, PKB, C-AKT |
| 2 | C | Glycogen synthase kinase-3 beta | polymer | 10 | 1123.2 | 1 | UniProt (P49841) In PDB | Homo sapiens | GSK-3 beta |
| 3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | A | 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine | non-polymer | 274.7 | 1 | Chemie (CQW) | |||
| 5 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 144 - 480 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 139 | - | expression tag |
| Ala 140 | - | expression tag |
| Met 141 | - | expression tag |
| Asp 142 | - | expression tag |
| Pro 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
| Ser 478 | Gly 478 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40731.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 329.6 | |
| All* | Total formula weight | 41061.0 |
